The emergence of depression in adolescence: development of the prefrontal cortex and the representation of reward.
Identifieur interne : 003787 ( Main/Exploration ); précédent : 003786; suivant : 003788The emergence of depression in adolescence: development of the prefrontal cortex and the representation of reward.
Auteurs : Christopher G. Davey [Australie] ; Murat Yücel ; Nicholas B. AllenSource :
- Neuroscience and biobehavioral reviews [ 0149-7634 ] ; 2008.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Animaux (MeSH), Cortex préfrontal (croissance et développement), Cortex préfrontal (physiopathologie), Dopamine (métabolisme), Frustration (MeSH), Humains (MeSH), Modèles psychologiques (MeSH), Psychologie de l'adolescent (MeSH), Récompense (MeSH), Trouble dépressif (métabolisme), Trouble dépressif (physiopathologie), Trouble dépressif (psychologie), Voies nerveuses (métabolisme).
- MESH :
- croissance et développement : Cortex préfrontal.
- métabolisme : Dopamine, Trouble dépressif, Voies nerveuses.
- physiopathologie : Cortex préfrontal, Trouble dépressif.
- psychologie : Trouble dépressif.
- Adolescent, Animaux, Frustration, Humains, Modèles psychologiques, Psychologie de l'adolescent, Récompense.
English descriptors
- KwdEn :
- Adolescent (MeSH), Animals (MeSH), Depressive Disorder (metabolism), Depressive Disorder (physiopathology), Depressive Disorder (psychology), Dopamine (metabolism), Frustration (MeSH), Humans (MeSH), Models, Psychological (MeSH), Neural Pathways (metabolism), Prefrontal Cortex (growth & development), Prefrontal Cortex (physiopathology), Psychology, Adolescent (MeSH), Reward (MeSH).
- MESH :
- chemical , metabolism : Dopamine.
- growth & development : Prefrontal Cortex.
- metabolism : Depressive Disorder, Neural Pathways.
- physiopathology : Depressive Disorder, Prefrontal Cortex.
- psychology : Depressive Disorder.
- Adolescent, Animals, Frustration, Humans, Models, Psychological, Psychology, Adolescent, Reward.
Abstract
Adolescent development is accompanied by the emergence of a population-wide increase in vulnerability to depression that is maintained through adulthood. We provide a model for understanding how this vulnerability to depression arises, and why depression is so often precipitated by social rejection or loss of status during this phase. There is substantial remodeling and maturation of the dopaminergic reward system and the prefrontal cortex during adolescence, that coincides with the adolescent entering the complex world of adult peer and romantic relationships, where the rewards that can be obtained (feelings such as belonging, romantic love, status and agency) are abstract and temporally distant from the proximal context. Development of the prefrontal cortex makes it possible to pursue such complex and distal rewards, which are, however, tenuous and more readily frustrated than more immediate rewards. We hypothesize that when these distant rewards are frustrated they suppress the reward system, and that when such suppression is extensive and occurs for long enough, the clinical picture that results is one of depression.
DOI: 10.1016/j.neubiorev.2007.04.016
PubMed: 17570526
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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We provide a model for understanding how this vulnerability to depression arises, and why depression is so often precipitated by social rejection or loss of status during this phase. There is substantial remodeling and maturation of the dopaminergic reward system and the prefrontal cortex during adolescence, that coincides with the adolescent entering the complex world of adult peer and romantic relationships, where the rewards that can be obtained (feelings such as belonging, romantic love, status and agency) are abstract and temporally distant from the proximal context. Development of the prefrontal cortex makes it possible to pursue such complex and distal rewards, which are, however, tenuous and more readily frustrated than more immediate rewards. We hypothesize that when these distant rewards are frustrated they suppress the reward system, and that when such suppression is extensive and occurs for long enough, the clinical picture that results is one of depression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17570526</PMID><DateCompleted><Year>2008</Year><Month>02</Month><Day>21</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0149-7634</ISSN><JournalIssue CitedMedium="Print"><Volume>32</Volume><Issue>1</Issue><PubDate><Year>2008</Year></PubDate></JournalIssue><Title>Neuroscience and biobehavioral reviews</Title><ISOAbbreviation>Neurosci Biobehav Rev</ISOAbbreviation></Journal><ArticleTitle>The emergence of depression in adolescence: development of the prefrontal cortex and the representation of reward.</ArticleTitle><Pagination><MedlinePgn>1-19</MedlinePgn></Pagination><Abstract><AbstractText>Adolescent development is accompanied by the emergence of a population-wide increase in vulnerability to depression that is maintained through adulthood. We provide a model for understanding how this vulnerability to depression arises, and why depression is so often precipitated by social rejection or loss of status during this phase. There is substantial remodeling and maturation of the dopaminergic reward system and the prefrontal cortex during adolescence, that coincides with the adolescent entering the complex world of adult peer and romantic relationships, where the rewards that can be obtained (feelings such as belonging, romantic love, status and agency) are abstract and temporally distant from the proximal context. Development of the prefrontal cortex makes it possible to pursue such complex and distal rewards, which are, however, tenuous and more readily frustrated than more immediate rewards. 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Allen</name><name sortKey="Yucel, Murat" sort="Yucel, Murat" uniqKey="Yucel M" first="Murat" last="Yücel">Murat Yücel</name></noCountry><country name="Australie"><region name="Victoria (État)"><name sortKey="Davey, Christopher G" sort="Davey, Christopher G" uniqKey="Davey C" first="Christopher G" last="Davey">Christopher G. Davey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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